Light-induced retinal injury enhanced neurotrophins secretion and neurotrophic effect of mesenchymal stem cells in vitro Lesão de retina induzida por luz aumentou a secreção de neurotrofinas e o efeito neurotrófico das células primordiais mesenquimais in vitro

Mesenchymal stem cells (MSCs) are self-renewal and multipotent cell source widely existed in mesenchymal tissues, which play a significant role in tissue regeneration and injury repair. It has been reported that MSCs are able to differentiate into multilineage tissue cells, including retinal cells, making MSCs an alternative therapeutic source for some irreversible retinal disorders such as age-related macular degeneration (AMD), retinitis pigmentosa (RP), glaucoma. However, clinical cell replacement is still far away unless technical barriers like directional differentiation, large scale output of target cells and reconstruction of the complicated network among the existed retinal cells and the regenerated cells were overcome. In addition, heterogeneous populations like multipotent adult progenitor cells (MAPCs), marrow-isolated adult multilineage inducible (MIAMI) cells, multipotent adult stem cells (MASCs) and very small embryonic-like stem cells (VSELs) may overlap in MSCs. The emerging evidence that MSCs are pericytes for the common features they shared. These make MSCs a controversial cell source. Nonetheless, MSCs are promising for its potential applications in neuroprotection and immunomodulation apart from tissue regeneration. Accumulating findings have indicated a neuroprotective role of MSCs in central nervous system (CNS) disorder as well as in retinal disorder. Neurotrophins secreted from MSCs promote the survival of host cells and the repair process during injury enabling MSCs an attractive therapeutic source for a variety of neurological disease, e.g. multiple sclerosis and stroke. Neurotrophic effect of MSCs was also reported in retinal disorders. MSCs attenuated cell death in retinal ganglion cells (RGCs) suffering from in vitro insult and promoted RGCs survival in glaucoma animal model. Systemic administration of MSCs delayed progress of retinal degeneration in RCS rats. These Light-induced retinal injury enhanced neurotrophins secretion and neurotrophic effect of mesenchymal stem cells in vitro